Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates

The dimeric Mycobacterium tuberculosis FabH (mtFabH) catalyses a Claisen-type condensation between an acyl-CoA and malonyl-Acyl Carrier Protein (ACP) to initiate the Type II fatty acid synthase cycle. To analyze the initial covalent acylation of mtFabH with acyl-CoA, we challenged it with mixture of...

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Detalhes bibliográficos
Main Authors: Sachdeva, Sarbjot, Musayev, Faik, Alhamadsheh, Mamoun M., Scarsdale, J. Neel, Wright, H. Tonie, Reynolds, Kevin A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293971/
https://ncbi.nlm.nih.gov/pubmed/18096200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2007.11.001
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