Replication of an E1B 55-Kilodalton Protein-Deficient Adenovirus (ONYX-015) Is Restored by Gain-of-Function Rather than Loss-of-Function p53 Mutants

ONYX-015 (dl1520) is an E1B 55-kilodalton protein-deficient replicating adenovirus that is currently in clinical trials as an antitumor agent. On the basis of the observation that the E1B 55kD gene product is able to bind to and inactivate p53, ONYX-015's mechanism of action is proposed to involve s...

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Publikašuvnnas:	J Virol
Váldodahkkit:	Hann, Byron, Balmain, Allan
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Microbiology (ASM) 2003
Fáttát:	Virus-Cell Interactions
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC229311/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14557644/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.21.11588-11595.2003
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