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Residue L143 of the Foot-and-Mouth Disease Virus Leader Proteinase Is a Determinant of Cleavage Specificity

The foot-and-mouth disease virus (FMDV) leader proteinase (L(pro)) self-processes inefficiently at the L(pro)/VP4 cleavage site LysLeuLys*GlyAlaGly (* indicates cleaved peptide bond) when the leucine at position P2 is replaced by phenylalanine. Molecular modeling and energy minimization identified t...

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Autors principals: Mayer, Christina, Neubauer, David, Nchinda, Aloysius T., Cencic, Regina, Trompf, Katja, Skern, Tim
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293068/
https://ncbi.nlm.nih.gov/pubmed/18305051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02077-07
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