NP, PB1, and PB2 Viral Genes Contribute to Altered Replication of H5N1 Avian Influenza Viruses in Chickens

The virulence determinants for highly pathogenic avian influenza viruses (AIVs) are considered multigenic, although the best characterized virulence factor is the hemagglutinin (HA) cleavage site. The capability of influenza viruses to reassort gene segments is one potential way for new viruses to e...

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Bibliographic Details
Main Authors: Wasilenko, Jamie L., Lee, Chang Won, Sarmento, Luciana, Spackman, Erica, Kapczynski, Darrell R., Suarez, David L., Pantin-Jackwood, Mary J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293025/
https://ncbi.nlm.nih.gov/pubmed/18305037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02642-07
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