Vaccine Protection by Live, Attenuated Simian Immunodeficiency Virus in the Absence of High-Titer Antibody Responses and High-Frequency Cellular Immune Responses Measurable in the Periphery

An attenuated derivative of simian immunodeficiency virus strain 239 deleted of V1-V2 sequences in the envelope gene (SIV239ΔV1-V2) was used for vaccine/challenge experiments in rhesus monkeys. Peak levels of viral RNA in plasma of 10(4) to 10(6.5) copies/ml in the weeks immediately following inocul...

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Detalhes bibliográficos
Main Authors: Mansfield, Keith, Lang, Sabine M., Gauduin, Marie-Claire, Sanford, Hannah B., Lifson, Jeffrey D., Johnson, R. Paul, Desrosiers, Ronald C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292994/
https://ncbi.nlm.nih.gov/pubmed/18272584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00015-08
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