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Linezolid Resistance in Staphylococcus aureus: Gene Dosage Effect, Stability, Fitness Costs, and Cross-Resistances

Linezolid resistance in Staphylococcus aureus is typically associated with mutations in the 23S rRNA gene. Here we show that the accumulation of a single point mutation, G2576T, in the different copies of this gene causes stepwise increases in resistance, impairment of the biological fitness, and cr...

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Detalhes bibliográficos
Main Authors: Besier, Silke, Ludwig, Albrecht, Zander, Johannes, Brade, Volker, Wichelhaus, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292563/
https://ncbi.nlm.nih.gov/pubmed/18212098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01098-07
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