Ex Vivo Induction of mRNA in Human Whole Blood as a New Platform of Drug and Dietary Supplement Development

PURPOSE: We introduced a new concept of ex vivo gene expression analysis (Mitsuhashi, Clin Chem 53:148–149, 2007), where drug action was simulated under physiological conditions. This model system was applied to study various fields of drug development. MATERIALS AND METHODS: Heparinized human whole...

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Detalhes bibliográficos
Main Authors: Mitsuhashi, Masato, Ogura, Mieko, Endo, Katsuya, Obara, Kazuhiko, Izutsu, Hiroshi, Targan, Stephan R., Maemura, Motoko, Tachikawa, Daisuke, Shinagawa, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2008
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292497/
https://ncbi.nlm.nih.gov/pubmed/18183479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-007-9510-2
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