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Structural Basis for Reduced Staphylocoagulase-mediated Bovine Prothrombin Activation
Staphylocoagulase (SC) is a protein secreted by the human pathogen, Staphylococcus aureus, that activates human prothrombin (ProT) by inducing a conformational change. SC-bound ProT efficiently clots fibrinogen, thus bypassing the physiological blood coagulation pathway. The crystal structure of a f...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2292465/ https://ncbi.nlm.nih.gov/pubmed/16230338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M507957200 |
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