Binding Cooperativity in Phage λ is Not Sufficient to Produce an Effective Switch

In the wild-type phage λ, binding of CI to O(R)2 helps polymerase bound to P(RM) transition from a closed to open complex. Activators on other promoters increase the polymerase-DNA binding energy, or affect both the binding energy and the closed-open transition probability. Using a validated mathema...

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Main Authors: Gedeon, Tomáš, Mischaikow, Konstantin, Patterson, Kathryn, Traldi, Eliane
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2008
Teme:
Biophysical Theory and Modeling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292370/
https://ncbi.nlm.nih.gov/pubmed/18400951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.121756
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