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Differential Contribution of IL-4 and STAT6 vs STAT4 to the Development of Lupus Nephritis

Mechanisms that initiate lupus nephritis and cause progression to end-stage renal disease remain poorly understood. In this study, we show that lupus-prone New Zealand Mixed 2410 mice that develop a severe glomerulosclerosis and rapidly progressive renal disease overexpress IL-4 in vivo. In these mi...

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Détails bibliographiques
Auteurs principaux: Singh, Ram Raj, Saxena, Vijay, Zang, Song, Li, Lily, Finkelman, Fred D., Witte, David P., Jacob, Chaim O.
Format: Artigo
Langue:Inglês
Publié: 2003
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291553/
https://ncbi.nlm.nih.gov/pubmed/12707364
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