Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism

AIMS: Oral L-arginine supplementation has been used in several studies to improve endothelium-dependent, nitric oxide (NO)-mediated vasodilation. L-Arginine treatment is hampered by extensive presystemic elimination due to intestinal arginase activity. In contrast, L-citrulline is readily absorbed a...

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Detalhes bibliográficos
Main Authors: Schwedhelm, Edzard, Maas, Renke, Freese, Ralf, Jung, Donald, Lukacs, Zoltan, Jambrecina, Alen, Spickler, William, Schulze, Friedrich, Böger, Rainer H
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Pharmacokinetics and Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291275/
https://ncbi.nlm.nih.gov/pubmed/17662090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02990.x
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