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A solid-phase Bcr-Abl kinase assay in 96-well hydrogel plates

Regulated phosphorylation by protein tyrosine kinases (PTKs) such as c-Abl, is critical to cellular homeostasis. In turn, once deregulated as in the Chronic Myeloid Leukemia (CML) fusion protein Bcr-Abl, PTKs can promote cancer onset and progression. The dramatic success of the Bcr-Abl inhibitor ima...

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Detalhes bibliográficos
Main Authors: Wu, Ding, Mand, Michael R., Veach, Darren R., Parker, Laurie L., Clarkson, Bayard, Kron, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291073/
https://ncbi.nlm.nih.gov/pubmed/18194660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.12.023
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