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Gating properties of girk channels activated by gα(o)- and Gα(i)-Coupled Muscarinic m2 Receptors in Xenopus Oocytes: The Role of Receptor Precoupling in RGS Modulation
‘Regulators of G protein Signalling’ (RGSs) accelerate the activation and deactivation kinetics of G protein-gated inwardly rectifying K(+) (GIRK) channels. In an apparent paradox, RGSs do not reduce steady-state GIRK current amplitudes as expected from the accelerated rate of deactivation when reco...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Blackwell Science Inc
2002
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290703/ https://ncbi.nlm.nih.gov/pubmed/12456817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.032151 |
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