Gating properties of girk channels activated by gα(o)- and Gα(i)-Coupled Muscarinic m2 Receptors in Xenopus Oocytes: The Role of Receptor Precoupling in RGS Modulation

‘Regulators of G protein Signalling’ (RGSs) accelerate the activation and deactivation kinetics of G protein-gated inwardly rectifying K(+) (GIRK) channels. In an apparent paradox, RGSs do not reduce steady-state GIRK current amplitudes as expected from the accelerated rate of deactivation when reco...

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Detalhes bibliográficos
Main Authors: Zhang, Qingli, Pacheco, Mary A, Doupnik, Craig A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290703/
https://ncbi.nlm.nih.gov/pubmed/12456817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.032151
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