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Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile
The leptin signal is transduced via the JAK2-STAT3 pathway at the leptin receptor. JAK2 also phosphorylates IRS, integral to insulin and leptin action and is required for optimum ABCA1-dependent transport of lipids from cells to apoA-I. We hypothesised that common variation in the JAK2 gene may be a...
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| Main Authors: | , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2008
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2289869/ https://ncbi.nlm.nih.gov/pubmed/18239666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oby.2007.79 |
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