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Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting

Members of the protein kinase C (PKC) family are characterized by an NH2-terminal regulatory domain containing binding sites for calcium, phosphatidylserine, and diacylglycerol (or tumor-promoting phorbol esters), a small central hinge region and a COOH-terminal catalytic domain. We have constructed...

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Dettagli Bibliografici
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1992
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289337/
https://ncbi.nlm.nih.gov/pubmed/1734020
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