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Reducing inositol lipid hydrolysis, Ins(1,4,5)P3 receptor availability, or Ca2+ gradients lengthens the duration of the cell cycle in Xenopus laevis blastomeres

We have microinjected a mAb specifically directed to phosphatidylinositol 4,5-bisphosphate (PIP2) into one blastomere of two- cell stage Xenopus laevis embryos. This antibody binds to endogenous PIP2 and reduces its rate of hydrolysis by phospholipase C. Antibody- injected blastomeres undergo partia...

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Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1992
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289269/
https://ncbi.nlm.nih.gov/pubmed/1309810
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