A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique

Selective allodepletion is a strategy to eliminate host-reactive donor T cells from hematopoietic stem cell allografts to prevent graft-versus-host disease while conserving useful donor immune functions. To overcome fluctuations in activation-based surface marker expression and achieve a more consis...

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Main Authors: Mielke, Stephan, Nunes, Raquel, Rezvani, Katayoun, Fellowes, Vicki S., Venne, Annie, Solomon, Scott R., Fan, Yong, Gostick, Emma, Price, David A., Scotto, Christian, Read, Elizabeth J., Barrett, A. John
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Transplantation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288732/
https://ncbi.nlm.nih.gov/pubmed/17878399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-104471
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