Cyr61/CCN1 and CTGF/CCN2 mediate the pro-angiogenic activity of VHL mutant renal carcinoma cells

The von Hippel-Lindau (VHL) protein serves as a negative regulator of hypoxia inducible factor-alpha subunit (HIF-α). Since HIF regulates critical angiogenic factors such as vascular endothelial growth factor (VEGF) and lesions in VHL gene are present in a majority of the highly vascularized renal c...

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Bibliografiske detaljer
Main Authors: Chintalapudi, Mastan R., Markiewicz, Margaret, Kose, Nurgun, Dammai, Vincent, Champion, Kristen J., Hoda, Rana S., Trojanowska, Maria, Hsu, Tien
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288647/
https://ncbi.nlm.nih.gov/pubmed/18212329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn019
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