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Correlation between β-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma

Aberrant Wnt-signaling caused by mutants of β-catenin, a key regulator of the canonical Wnt-signaling pathway, is frequently detected in cancer. Only recently, it was suggested that in hepatocellular carcinoma (HCC) the expression of the target gene glutamine synthetase (GS) is a highly reliable mar...

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Detalhes bibliográficos
Main Authors: Austinat, Madeleine, Dunsch, Ruediger, Wittekind, Christian, Tannapfel, Andrea, Gebhardt, Rolf, Gaunitz, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2287186/
https://ncbi.nlm.nih.gov/pubmed/18282277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-7-21
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