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The folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stability

Like most extracellular bacterial proteases, Streptomyces griseus protease B (SGPB) and α-lytic protease (αLP) are synthesized with covalently attached pro regions necessary for their folding. In this article, we characterize the folding free energy landscape of SGPB and compare it to the folding la...

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Detalles Bibliográficos
Main Authors: Truhlar, Stephanie M.E., Cunningham, Erin L., Agard, David A.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286692/
https://ncbi.nlm.nih.gov/pubmed/14718653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03336804
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