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The folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stability

Like most extracellular bacterial proteases, Streptomyces griseus protease B (SGPB) and α-lytic protease (αLP) are synthesized with covalently attached pro regions necessary for their folding. In this article, we characterize the folding free energy landscape of SGPB and compare it to the folding la...

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Bibliografiska uppgifter
Huvudupphovsmän: Truhlar, Stephanie M.E., Cunningham, Erin L., Agard, David A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2004
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286692/
https://ncbi.nlm.nih.gov/pubmed/14718653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03336804
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