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Insertion of the cytochrome b(5) heme-binding loop into an SH3 domain. Effects on structure and stability, and clues about the cytochrome’s architecture

Under native conditions, apocytochrome b(5) exhibits a stable core and a disordered heme-binding region that refolds upon association with the cofactor. The termini of this flexible region are in close proximity, suggesting that loop closure may contribute to the thermodynamic properties of the apoc...

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Bibliografiske detaljer
Main Authors: Knappenberger, Jane A., Kraemer-Pecore, Christina M., Lecomte, Juliette T.J.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286592/
https://ncbi.nlm.nih.gov/pubmed/15459337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04902704
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