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CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis

Previously, we described an APC-adenovirus (APC-Ad) FasL cell gene therapy method which could be used to deplete autoreactive T cells in vivo. FasL was toxic, however, and controlled regulation of FasL was not achieved. Here we describe an improved approach to delivering TNF-related apoptosis-induci...

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Uloženo v:
Vydáno v:J Clin Invest
Hlavní autoři: Liu, Zhongyu, Xu, Xin, Hsu, Hui-Chen, Tousson, Albert, Yang, Ping-Ar, Wu, Qi, Liu, Cunren, Yu, Shaohua, Zhang, Huang-Ge, Mountz, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2003
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC228459/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14597760/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI19209
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