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Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function

Aryl hydrocarbon receptor nuclear translocator (ARNT), a transcription factor of the Per/AHR/ARNT/Sim family, regulates gene expression in response to environmental stimuli including xenobiotics and hypoxia. To examine its role in the epidermis, the Cre-loxP system was used to disrupt the Arnt gene...

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Udgivet i:J Clin Invest
Principais autores: Takagi, Satoshi, Tojo, Hiromasa, Tomita, Shuhei, Sano, Shigetoshi, Itami, Satoshi, Hara, Mariko, Inoue, Shintaro, Horie, Kyoji, Kondoh, Gen, Hosokawa, Ko, Gonzalez, Frank J., Takeda, Junji
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC228437/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14597763/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI18513
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