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Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro

Mitochondria have been proposed to possess base excision repair processes to correct oxidative damage to the mitochondrial genome. As the only DNA polymerase (pol) present in mitochondria, pol γ is necessarily implicated in such processes. Therefore, we tested the ability of the catalytic subunit of...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Longley, Matthew J., Prasad, Rajendra, Srivastava, Deepak K., Wilson, Samuel H., Copeland, William C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1998
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22816/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9770471/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.21.12244
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