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Analysis of the stability of multimeric proteins by effective ΔG and effective m-values

Analyzing the stability of a multimeric protein is challenging because of the intrinsic difficulty in handling the mathematical model for the folded multimer-unfolded monomer equilibrium. To circumvent this problem, we introduce the concept of effective stability, ΔG(eff) (= −RTlnK(eff)), where K(ef...

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Detalles Bibliográficos
Main Authors: Park, Chiwook, Marqusee, Susan
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2280007/
https://ncbi.nlm.nih.gov/pubmed/15322294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04811004
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