Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein

Dehydroquinate synthase (DHQS) is the N-terminal domain of the pentafunctional AROM protein that catalyses steps 2 to 7 in the shikimate pathway in microbial eukaryotes. DHQS converts 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) to dehydroquinate in a reaction that includes alcohol oxidation,...

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Detalhes bibliográficos
Main Authors: Park, Alison, Lamb, Heather K., Nichols, Charlie, Moore, Jonathan D., Brown, Katherine A., Cooper, Alan, Charles, Ian G., Stammers, David K., Hawkins, Alastair R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279823/
https://ncbi.nlm.nih.gov/pubmed/15273308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04705404
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