Crystal structure and substrate specificity of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus

β-Ketoacyl-ACP synthase III (FabH), an essential enzyme for bacterial viability, catalyzes the initiation of fatty acid elongation by condensing malonyl-ACP with acetyl-CoA. We have determined the crystal structure of FabH from Staphylococcus aureus, a Gram-positive human pathogen, to 2 Å resolution...

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Bibliografiset tiedot
Päätekijät: Qiu, Xiayang, Choudhry, Anthony E., Janson, Cheryl A., Grooms, Michael, Daines, Robert A., Lonsdale, John T., Khandekar, Sanjay S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2005
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279320/
https://ncbi.nlm.nih.gov/pubmed/15987898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051501605
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