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Mutational Analysis of Ctnnb1 and Apc in Tumors from Rats Given 1,2-Dimethylhydrazine or 2-Amino-3-methylimidazo[4,5-f]quinoline: Mutational ‘Hotspots’ and the Relative Expression of β-Catenin and c-jun

There is growing interest in β-catenin and its role in various human cancers. We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for β-catenin, but the mutation spectrum was inf...

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Detalhes bibliográficos
Main Authors: Blum, Carmen A., Tanaka, Tomoko, Zhong, Xiaoying, Li, Qingjie, Dashwood, Wan-Mohaiza, Pereira, Clifford, Xu, Meirong, Dashwood, Roderick H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279233/
https://ncbi.nlm.nih.gov/pubmed/12669311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.10112
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