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Tl(+)-induced μs Gating of Current Indicates Instability of the MaxiK Selectivity Filter as Caused by Ion/Pore Interaction

Patch clamp experiments on single MaxiK channels expressed in HEK293 cells were performed at high temporal resolution (50-kHz filter) in asymmetrical solutions containing 0, 25, 50, or 150 mM Tl(+) on the luminal or cytosolic side with [K(+)] + [Tl(+)] = 150 mM and 150 mM K(+) on the other side. Out...

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Detalhes bibliográficos
Main Authors: Schroeder, Indra, Hansen, Ulf-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279167/
https://ncbi.nlm.nih.gov/pubmed/18378799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200809956
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