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Inhibition of creatine kinase reduces the rate of fatigue-induced decrease in tetanic [Ca(2+)](i) in mouse skeletal muscle

1. Ca(2+)-phosphate (P(i)) precipitation in the sarcoplasmic reticulum (SR) may cause reduced SR Ca(2+) release in skeletal muscle fatigue. To study this, we inhibited the creatine kinase (CK) reaction with 2,4-dinitro-1-fluorobenzene (DNFB). The hypothesis was that with inhibition of CK, phosphocre...

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Autores principales: Dahlstedt, Anders J, Westerblad, Håkan
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2001
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278666/
https://ncbi.nlm.nih.gov/pubmed/11410623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.00639.x
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