Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage

1. The acidic interior of neuroendocrine secretory vesicles provides both an energy gradient for amine-proton exchangers (VMATs) to concentrate small transmitter molecules, for example catecholamines, and an optimal pH for the prohormone convertases which cleave hormone precursors. There is evidence...

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Detalhes bibliográficos
Main Authors: Blackmore, Colin G, Varro, Andrea, Dimaline, Rod, Bishop, Lisa, Gallacher, David V, Dockray, Graham J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278512/
https://ncbi.nlm.nih.gov/pubmed/11251044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0605h.x
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