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Synergistic Fitness Interactions and a High Frequency of Beneficial Changes Among Mutations Accumulated Under Relaxed Selection in Saccharomyces cerevisiae
Spontaneous mutations were accumulated for ∼4800 generations in 48 lines of yeast protected from effective selection by frequent passage through single-cell bottlenecks. Changes in fitness were evaluated by direct competition with matched parental stocks differing only at a selectively neutral marke...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2278098/ https://ncbi.nlm.nih.gov/pubmed/18245361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.080853 |
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