Binding of Myotrophin/V-1 to Actin-capping Protein: IMPLICATIONS FOR HOW CAPPING PROTEIN BINDS TO THE FILAMENT BARBED END

The heterodimeric actin-capping protein (CP) regulates actin assembly and cell motility by binding tightly to the barbed end of the actin filament. Here we demonstrate that myotrophin/V-1 binds directly to CP in a 1:1 molar ratio with a K(d) of 10–50 nM. V-1 binding inhibited the ability of CP to ca...

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Bibliographic Details
Main Authors: Bhattacharya, Nandini, Ghosh, Shatadal, Sept, David, Cooper, John A.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277501/
https://ncbi.nlm.nih.gov/pubmed/16895918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M606278200
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