Abolition of Ca(2+)-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca(2+)-dependent K(+) channel Kcnn4

Intestinal fluid secretion is driven by apical membrane, cystic fibrosis transmembrane conductance regulator (CFTR)-mediated efflux of Cl– that is concentrated in cells by basolateral Na(+)−K(+)−2Cl– cotransporters (NKCC1). An absolute requirement for Cl– efflux is the parallel activation of K(+) ch...

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Bibliographische Detailangaben
Hauptverfasser: Flores, Carlos A, Melvin, James E, Figueroa, Carlos D, Sepúlveda, Francisco V
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2007
Schlagworte:
Alimentary
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277011/
https://ncbi.nlm.nih.gov/pubmed/17584847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.134387
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