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Abolition of Ca(2+)-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca(2+)-dependent K(+) channel Kcnn4
Intestinal fluid secretion is driven by apical membrane, cystic fibrosis transmembrane conductance regulator (CFTR)-mediated efflux of Cl– that is concentrated in cells by basolateral Na(+)−K(+)−2Cl– cotransporters (NKCC1). An absolute requirement for Cl– efflux is the parallel activation of K(+) ch...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2277011/ https://ncbi.nlm.nih.gov/pubmed/17584847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.134387 |
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