Programmed death-1 ligands-transfected dendritic cells loaded with glutamic acid decarboxylase 65 (GAD65) inhibit both the alloresponse and the GAD65-reactive lymphocyte response

Type 1 diabetes (T1D) is due to a loss of immune tolerance to islet antigens, such as glutamic acid decarboxylase 65 (GAD65), for which islet transplantation is a promising therapy. Therefore, the generation of tolerance aiming at both alloantigen and GAD65 will help therapeutic intervention greatly...

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Dettagli Bibliografici
Autori principali: He, F-R, Zhu, H-F, Huang, H, Dai, Y D, Shen, X, Wang, M, Li, L, Xing, W, Shen, G-X
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2008
Soggetti:
Translational Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276913/
https://ncbi.nlm.nih.gov/pubmed/18005363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2007.03546.x
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