A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor γ-chain complex

Platelet adhesion to vascular subendothelium, mediated in part by interactions between collagen and glycoprotein VI (GPVI) complexed with Fc receptor γ-chain, is crucial for thrombus formation. Antiplatelet therapy benefits patients with various thrombotic and ischemic diseases, but the safety and e...

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Egile Nagusiak: Takayama, Hiroshi, Hosaka, Yoshitaka, Nakayama, Kazuyuki, Shirakawa, Kamon, Naitoh, Katsuki, Matsusue, Tomokazu, Shinozaki, Mikihiko, Honda, Motoyasu, Yatagai, Yukiko, Kawahara, Tetsushi, Hirose, Jiro, Yokoyama, Tooru, Kurihara, Michiru, Furusako, Shoji
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2008
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276394/
https://ncbi.nlm.nih.gov/pubmed/18382762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32513
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