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Polyglutamine Expansion Reduces the Association of TATA-binding Protein with DNA and Induces DNA Binding-independent Neurotoxicity

TATA-binding protein (TBP) is essential for eukaryotic gene transcription. Human TBP contains a polymorphic polyglutamine (polyQ) domain in its N terminus and a DNA-binding domain in its highly conserved C terminus. Expansion of the polyQ domain to >42 glutamines typically results in spinocerebel...

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Autors principals: Friedman, Meyer J., Wang, Chuan-En, Li, Xiao-Jiang, Li, Shihua
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276379/
https://ncbi.nlm.nih.gov/pubmed/18218637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709674200
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