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Rumi, a CAP10 domain protein, is a glycosyltransferase that modifies Notch and is required for Notch signaling
Notch signaling is broadly used to regulate cell fate decisions. We have identified a novel gene, rumi, with a temperature-sensitive Notch phenotype. At 28-30°C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18°C only a mild Notch phenotype is evident. I...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275919/ https://ncbi.nlm.nih.gov/pubmed/18243100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.12.016 |
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