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NMR and mutagenesis of human Copper Transporter 1 (hCtr1) show that Cys-189 is required for correct folding and dimerization

The human high-affinity copper transporter (hCtr1) is a membrane protein that is predicted to have three transmembrane helices and two methionine-rich metal binding motifs. As an oligomeric polytopic membrane protein, hCtr1 is a challenging system for experimental structure determination. The result...

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Main Authors: Lee, Sangwon, Howell, Stephen B., Opella, Stanley J.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275670/
https://ncbi.nlm.nih.gov/pubmed/17959139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2007.08.037
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