Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage

The zinc finger transcription factor GATA-1 requires direct physical interaction with the cofactor friend of GATA-1 (FOG-1) for its essential role in erythroid and megakaryocytic development. We show that in the mast cell lineage, GATA-1 functions completely independent of FOG proteins. Moreover, we...

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Bibliographic Details
Main Authors: Cantor, Alan B., Iwasaki, Hiromi, Arinobu, Yojiro, Moran, Tyler B., Shigematsu, Hirokazu, Sullivan, Matthew R., Akashi, Koichi, Orkin, Stuart H.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275384/
https://ncbi.nlm.nih.gov/pubmed/18299398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070544
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