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Synergistic Impairment of Glucose Homeostasis in ob/ob Mice Lacking Functional Serotonin 2C Receptors

To investigate how serotonin and leptin interact in the regulation of energy balance and glucose homeostasis, we generated a genetic mouse model, the OB2C mouse, which lacks functional serotonin 2C receptors and the adipocyte hormone leptin. The OB2C mice exhibited a dramatic diabetes phenotype, evi...

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Dettagli Bibliografici
Autori principali: Wade, Jennifer M., Juneja, Punita, MacKay, Adrienne W., Graham, James, Havel, Peter J., Tecott, Laurence H., Goulding, Evan H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Endocrine Society 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275362/
https://ncbi.nlm.nih.gov/pubmed/18039786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-0927
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