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Altered expression of KIF17, a kinesin motor protein associated with NR2B trafficking, may mediate learning deficits in a Down syndrome mouse model
OBJECTIVE: Down syndrome (DS) a major cause of mental retardation affects 1/800 newborns. Mouse models for Down syndrome have been studied and found to have developmental and learning deficits, including the Ts65Dn (DS) mouse model. NMDA receptor NR2B subunit enhances synaptic plasticity. Upregulati...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2274888/ https://ncbi.nlm.nih.gov/pubmed/18313453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajog.2008.01.033 |
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