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Decreased aminoacylation in pathology-related mutants of mitochondrial tRNA(Tyr) is associated with structural perturbations in tRNA architecture
A growing number of human pathologies are ascribed to mutations in mitochondrial tRNA genes. Here, we report biochemical investigations on three mt-tRNA(Tyr) molecules with point substitutions associated with diseases. The mutations occur in the atypical T- and D-loops at positions homologous to tho...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2271369/ https://ncbi.nlm.nih.gov/pubmed/18268021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.938108 |
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