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Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities
Progranulin is a secreted protein with important functions in several physiological and pathological processes, such as embryonic development, host defense, and wound repair. Autosomal dominant mutations in the progranulin gene cause frontotemporal dementia, while overexpression of progranulin promo...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2271164/ https://ncbi.nlm.nih.gov/pubmed/18359860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073295308 |
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