Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates

Loss of function mutations in the receptor tyrosine kinase TrkB pathway resulted in hyperphagia and morbid obesity in human and rodents. Conversely, peripheral or central stimulation of TrkB by its natural ligands BDNF or NT4 reduced body weight and food intake in mice, supporting the idea that TrkB...

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Detalhes bibliográficos
Main Authors: Lin, John C., Tsao, David, Barras, Paul, Bastarrachea, Raul A., Boyd, Bob, Chou, Joyce, Rosete, Rodnie, Long, Hua, Forgie, Alison, Abdiche, Yasmina, Dilley, Jeanette, Stratton, Jennifer, Garcia, Carlos, Sloane, David L., Comuzzie, Anthony G., Rosenthal, Arnon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270901/
https://ncbi.nlm.nih.gov/pubmed/18382675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001900
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