Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20

BACKGROUND: Rituximab is used in the treatment of CD20(+) B cell lymphomas and other B cell lymphoproliferative disorders. Its clinical efficacy might be further improved by combinations with other drugs such as statins that inhibit cholesterol synthesis and show promising antilymphoma effects. The...

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Main Authors: Winiarska, Magdalena, Bil, Jacek, Wilczek, Ewa, Wilczynski, Grzegorz M, Lekka, Malgorzata, Engelberts, Patrick J, Mackus, Wendy J. M, Gorska, Elzbieta, Bojarski, Lukasz, Stoklosa, Tomasz, Nowis, Dominika, Kurzaj, Zuzanna, Makowski, Marcin, Glodkowska, Eliza, Issat, Tadeusz, Mrowka, Piotr, Lasek, Witold, Dabrowska-Iwanicka, Anna, Basak, Grzegorz W, Wasik, Maria, Warzocha, Krzysztof, Sinski, Maciej, Gaciong, Zbigniew, Jakobisiak, Marek, Parren, Paul W. H. I, Golab, Jakub
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270297/
https://ncbi.nlm.nih.gov/pubmed/18366248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0050064
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