Failure to detect abnormal prion protein and scrapie-associated fibrils 6 wk after intracerebral inoculation of genetically susceptible sheep with scrapie agent

Detection of the scrapie-associated protease-resistant prion protein (PrP(res)) in sheep brains in the early phase after intracerebral inoculation of the scrapie agent has not been documented. Fourteen 4-mo-old, genetically susceptible lambs (QQ homozygous at codon 171 of the PrP gene) were obtained...

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Autores principales: Hamir, Amir N., Miller, Janice M., Stack, Mick J., Chaplin, Melanie J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2002
Materias:
Short Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC227019/
https://ncbi.nlm.nih.gov/pubmed/12418787
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