Effects of the immunosuppressant FK506 on intracellular Ca(2+) release and Ca(2+) accumulation mechanisms

1. The immunophilin FKBP12 associates with intracellular Ca(2+) channels and this interaction can be disrupted by the immunosuppressant FK506. We have investigated the effect of FK506 on Ca(2+) release and Ca(2+) uptake in permeabilized cell types. 2. Changes in medium free [Ca(2+)] were detected by...

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Autores principales: Bultynck, Geert, De Smet, Patrick, Weidema, A Frederik, Ver Heyen, Mark, Maes, Karlien, Callewaert, Geert, Missiaen, Ludwig, Parys, Jan B, De Smedt, Humbert
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2000
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269973/
https://ncbi.nlm.nih.gov/pubmed/10856121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.t01-1-00681.x
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