12-Lipoxygenase overexpression in rodent NG108-15 cells enhances membrane excitability by inhibiting M-type K(+) channels

1. 12-Lipoxygenase produces 12-hydroperoxy acid from arachidonic acid released from membrane phospholipids. To elucidate the role of the enzyme in neuronal functions, mouse neuroblastoma × rat glioma hybrid NG108-15 cells were permanently transfected with the cDNA for human 12-lipoxygenase. 2. The n...

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Bibliographic Details
Main Authors: Takahashi, Yoshitaka, Kawajiri, Hiroo, Yoshimoto, Tanihiro, Hoshi, Naoto, Higashida, Haruhiro
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 1999
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269696/
https://ncbi.nlm.nih.gov/pubmed/10601489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1999.00567.x
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