Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes

1. Whole-cell Na(+) currents (holding potential, −80 mV; test potential, −30 mV) in rat myocytes were inhibited by 8,9-epoxyeicosatrienoic acid (8,9-EET) in a dose-dependent manner with 22 ± 4 % inhibition at 0.5 μM, 48 ± 5 % at 1 μM, and 73 ± 5 % at 5 μM (mean ± s.e.m., n = 10, P < 0.05 for each...

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Detalhes bibliográficos
Main Authors: Lee, Hon-Chi, Lu, Tong, Weintraub, Neal L, VanRollins, Mike, Spector, Arthur A, Shibata, Erwin F
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269481/
https://ncbi.nlm.nih.gov/pubmed/10432346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1999.0153o.x
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